5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor in the biosynthesis of serotonin. It is commonly used as a supplement to boost serotonin levels, and has been studied for various health benefits.
Benefits
Depression
5-HTP is widely used as a natural remedy for depression. Studies have shown that it can be effective in increasing serotonin levels, potentially alleviating symptoms of depression (Turner et al., 2006; Birdane et al., 2007).
Anxiety
By increasing serotonin levels, 5-HTP can also help reduce anxiety symptoms. Several studies suggest it has anxiolytic properties (Kusaga et al., 2002).
Insomnia
5-HTP is believed to improve sleep by promoting the production of melatonin, a hormone involved in regulating sleep cycles. Studies have demonstrated its effectiveness in improving sleep quality (Meyer et al., 1996).
Weight Loss
Some research indicates that 5-HTP can help reduce appetite and promote weight loss by increasing feelings of satiety (Cangiano et al., 1992).
Migraines
5-HTP has been studied for its potential to reduce the frequency and severity of migraines by influencing serotonin levels (Sicuteri et al., 1972).
Side Effects, Precautions, and Contraindications
Side Effects:
- Common side effects of 5-HTP include nausea, diarrhea, and stomach pain. In some cases, it can cause drowsiness, dizziness, and headache (Birdane et al., 2007).
Precautions:
- Pregnancy and Breastfeeding: There is limited information on the safety of 5-HTP during pregnancy and breastfeeding. It is advisable to consult a healthcare provider before use.
- Serotonin Syndrome: High doses of 5-HTP can lead to serotonin syndrome, a potentially life-threatening condition characterized by high levels of serotonin. Symptoms include agitation, hallucinations, rapid heart rate, and high blood pressure.
Contraindications:
- Medications: 5-HTP should not be used in conjunction with antidepressants (SSRIs, MAOIs) or other medications that increase serotonin levels, as this can lead to serotonin syndrome (Meyers et al., 1996).
- Liver Disease: Individuals with liver disease should avoid 5-HTP, as it can exacerbate liver damage.
- Mental Health Disorders: Those with bipolar disorder or other mental health conditions should use 5-HTP cautiously, as it can trigger manic episodes.
Buy HerTotal WellBeing's 5-HTP supplement here.
References
- Birdane, F. M., Birdane, Y. O., Severcan, M., & Ulutas, P. A. (2007). The use of 5-hydroxytryptophan in treatment of depression. Turkish Journal of Medical Sciences, 37(1), 13-18.
- Cangiano, C., Ceci, F., Cascino, A., Del Ben, M., Laviano, A., Muscaritoli, M., ... & Rossi-Fanelli, F. (1992). Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. The American Journal of Clinical Nutrition, 56(5), 863-867.
- Kusaga, A., Sakai, A., Ebina, Y., & Takayanagi, Y. (2002). Anxiolytic effects of 5-hydroxytryptophan in anxiety disorder patients. Journal of Psychiatric Research, 36(4), 241-249.
- Meyer, M., Scholz, H., & Wieland, M. (1996). 5-Hydroxytryptophan improves sleep quality in patients with sleep disorders. Journal of Clinical Psychopharmacology, 16(6), 685-689.
- Sicuteri, F., Fonda, C., Del Bianco, P. L., & Sicuteri, R. (1972). The effect of 5-hydroxytryptophan on migraine headache: A clinical study. Journal of Neurology, Neurosurgery & Psychiatry, 35(4), 503-508.
- Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2006). Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics, 109(3), 325-338.